But for some the challenge is almost unimaginably greater – and completing the 26 miles will mark a far greater achievement than simply the pride of picking up a medal.
Like all competitors in this year's marathon, Claire Lomas, 31, and Rob Long, 24, have been training for months to prepare for the event, but their journey to even reach the start line has meant overcoming hurdles that few other runners will have faced.
Miss Lomas, a former champion equestrian events rider, was paralysed from the waist down after a riding accident five years ago but with the aid of a pair of robotic legs walked again for the first time earlier this year.
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